Drug Study 2o5z4u

c Vitamin B complex essential for nucleoprotein synthesis and maintenance of normal erythropoiesis. Acts against folic acid deficiency that impairs thymidylate synthesis and results in production of defective DNA that leads to megaloblast formation and arrest of bone marrow maturation. Vitamin B9 Folate deficiency, macrocytic anemia, and megaloblastic anemias associated with malabsorption syndromes, alcoholism, primary liver disease, inadequate dietary intake, pregnancy, infancy, and childhood.

c Angiotensin II receptor (type AT1) antagonist acts as a potent vasoconstrictor and primary vasoactive hormone of the renin±angiotensin±aldosterone system. Cardiovascular agent; angiotensin ii receptor antagonist; antihypertensive Hypertension

c Lowers blood pressure by specific inhibition of the angiotensin-converting enzyme (ACE). This interrupts conversion sequences initiated by renin that lead to formation of angiotensin II, a

potent endogenous vasoconstrictor. ACE inhibition alters hemodynamic without compensatory reflex tachycardia or changes in cardiac output (except in patients with CHF). Peripheral vascular resistance is lowered by vasodilatation. Inhibition of ACE also leads to decreased circulating aldosterone. Reduced circulating aldosterone is associated with a potassium-sparing effect. In heart failure, captopril istration is followed by a fall in CVP and pulmonary wedge pressure; hypotensive action appears to be unrelated to plasma rennin levels. Cardiovascular agent; angiotensin-converting enzyme (ace) inhibitor; antihypertensive agent Hypertension; in conjunction with digitalis and diuretics in CHF, diabetic nephropathy.